Managing Side Effects on Semaglutide: A Practical Guide

Why Side Effects Happen

Semaglutide works by slowing gastric emptying and modulating appetite hormones in the brain. These mechanisms — while effective for weight loss — can cause gastrointestinal discomfort, especially during the first 4-6 weeks and during dose increases.

Managing Nausea

Eat smaller, more frequent meals. Prioritize protein and vegetables over fatty, greasy, or sugary foods. Ginger tea has modest anti-nausea evidence. Take oral semaglutide in the morning on an empty stomach. If nausea persists beyond 6 weeks, your provider may adjust your titration schedule.

Dealing with Constipation

Increase fiber intake gradually (aim for 25-30g daily). Drink at least 64oz of water per day. Gentle movement like walking helps stimulate digestion. A fiber supplement or stool softener can help if dietary changes aren't sufficient — ask your Clyne provider.

When to Contact Your Provider

Contact your care team if: you can't keep food or liquids down for 24+ hours, you experience severe abdominal pain, you're losing weight faster than 4 lbs per week, or symptoms significantly worsen after being stable.